Cyberpunk exists within its own fictional timeline, which splits from the real world in 1990. The timeline has been extended with each major edition of the game, from the first edition set in 2013 to Cyberpunk Red set in 2045.
Major events have included the collapse of the global superpowers, and the rise of Megacorporations that fight amongst themselves for dominance. Food blights have caused disastrous famines, and by the late 1990s the Middle East is a radioactive desert. Bioengineering, against a backdrop of warfare, has resulted in the rapid development of cybernetic prosthetics and direct human-machine interfaces. With the lack of government and police, casual violence is endemic. Many also suffer from "technoshock", an inability to cope with a world of synthetic muscle tissue, organic circuits and designer drugs.
The main location for Cyberpunk is the fictional Night City, situated on the west coast of the United States between Los Angeles and San Francisco. With a population of five million people, it presents a stratified society of gang warfare, corporate rivalries and political machinations in which the players have to survive.